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The following CVspectrum animations are narrated educational videos on various topics.
You can view the animation videos online or download them to your own computer.
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Understanding Metabolic Origins of Dyslipoproteinemia(Playing Time: 10:54)
The complex
choreography of the lipid transportation and utilization systems is essential
for the normal supply, exchange, and clearance of cholesterol and triglycerides
in the body. The functional integration of lipoproteins, apolipoproteins,
enzymes, transporters, and receptors in this system is a delicate physiologic
balance. Disruption of one or more components of this system can tip the
balance, creating dyslipoproteinemias that promote accumulation of cholesterol
in the arterial wall. This animation will review the metabolic origins of
dyslipoproteinemia, including that seen in atherogenic dyslipidemia, familial
hypercholesterolemia, and the metabolic syndrome.
Play
Dial Up (Windows, Real Player)
Cable/Broadband/DSL (Windows, Real Player)
Download
Metabolic Origins.Zip (Windows, Real Player)
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Physiology of Lipoprotein Metabolism(Playing time: 07:56)
A key to
the effective treatment of cardiovascular disease is understanding the body’s
complex lipoprotein transport system. At the operational helm are
apolipoproteins, which, through their various functions such as enzyme
activation and receptor binding, choreograph the transport of lipids from sites
of absorption or synthesis to sites of utilization. This video provides an
animated review of the physiology of lipoprotein metabolism, including the Apo
A1 (high-density lipoprotein cholesterol [HDL-C]) and Apo B (non-HDL-C)
metabolic pathways.
Play
Dial Up (Windows, Real Player)
Cable/Broadband/DSL (Windows, Real Player)
Download
Physiology.Zip (Windows, Real Player)
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The following animation includes 3 different clips. (Playing time: 09:46)
New Concepts in Lipoprotein Metabolism(Playing time: 02:10)
Reducing
atherogenic burden is one of the greatest challenges for today’s physician
facing the epidemic of atherosclerosis. Fortunately, research is yielding deep
insights to meet this challenge. Recent decades of study have proved that
lowering low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular
disease, yet many cardiovascular events occur without the presence of
significant elevations of LDL-C. Newer data are demonstrating the atherogenic
potential of lipoprotein particles other than LDL-C. This video will provide an
animated review of emerging concepts in lipoprotein metabolism, including
exciting new potentials for therapeutic targets.
Characterization of Lipoproteins (Playing time: 04:36)
The treatment
of dyslipidemia is continuing to evolve from a science previously grounded in
the measurement of the lipid cargo (ie, total cholesterol and triglycerides) to
a science focused on the more sophisticated determination of the functionality
of lipid transport pathways. Research is revealing complex interrelationships
between lipoprotein particles, receptors, and enzymes necessary for functional
lipid distribution. This animation will review the key players of these
processes.
Definition and Significance of Non-HDL Cholesterol (Playing time: 03:00)
Revelations
about the unique combination and function of the apolipoproteins on each
particle are continuing to advance our knowledge of lipoprotein dynamics and the
distribution of their cholesterol and triglyceride content. Accordingly, our
evaluation of fasting plasma lipids continues to evolve. Over the years,
guidelines have shifted from the measurement of total cholesterol and
triglyceride content in the plasma, to a refined focus on LDL-C and HDL-C. While
LDL-C is clearly recognized as the major atherogenic particle, new evidence
indicates that increased levels of other triglyceride-rich lipoproteins
including intermediate-density lipoprotein (IDL), very-low-density lipoprotein
(VLDL), and chylomicron remnants also contribute to cholesterol accumulation in
the arterial wall. This animation will review these constituents of “non-HDL-C”
and their utility.
Play
Dial Up (Windows, Real Player)
Cable/Broadband/DSL (Windows, Real Player)
Download
New Concepts.Zip (Windows, Real Player)
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To view the presentations, you must have Windows Media Player or RealNetworks Real Player installed. Click the icon of the appropriate media player for a free download.
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